domingo, 17 de noviembre de 2013

Diabetes control shark antibody

Mexican scientists managed to stop some adverse effects of diabetes mellitus using antibody molecules derived from a shark living in the Sea of ​​Cortez and is popularly known as Horned Shark (Heterodontus francisci).
En la medicina contemporánea hay una corriente de investigación que trabaja con anticuerpos de diferentes especies animales como el caballo, el camello y la llama. In modern medicine there is a stream of research that works with antibodies from different animal species such as the horse, camel and llama. En México, el Centro de Investigación Científica y Educación Superior de Ensenada (CICESE) y del Laboratorio Silanes crearon una alianza para investigar los posibles usos terapéuticos de los anticuerpos de tiburón. In Mexico, the Center for Scientific Research and Higher Education of Ensenada (CICESE) Silanes Laboratory and created a partnership to investigate potential therapeutic uses of shark antibodies.
Los compuestos que se pueden obtener gracias a la técnica de anticuerpos de tiburón, son capaces de atrapar y neutralizar a algunas moléculas presentes en el cuerpo humano y que ponen en marcha procesos de inflamación y de neovascularización. The compounds obtainable through the shark antibody technique, are able to catch and neutralize some molecules present in the human body and that implement processes of inflammation and neovascularization. También se le ha reconocido a estos compuestos alguna efectividad en contra de procesos autoinmunes y tumorales, así como en la diabetes. It has also been recognized effectiveness of these compounds against some autoimmune processes and tumor as well as in diabetes.
La innovación mexicana ya fue reconocida por el gobierno de Estados Unidos, que otorgó un registro de patente para la explotación comercial de lo que describe como una nueva tecnología para elaborar fármacos. Mexican Innovation and was recognized by the U.S. government, which granted a patent registration for commercial exploitation of what he describes as a new technology to develop drugs.
Este hallazgo es único a nivel mundial y además de tener la posibilidad de generar nuevos compuestos terapéuticos útiles en el tratamiento de la diabetes, también tiene aplicaciones en el tratamiento de la artritis. This finding is unique worldwide, and besides having the ability to generate new therapeutic compounds useful in the treatment of diabetes, also has applications in the treatment of arthritis.
La patente fue otorgada después de un extenso proceso de análisis de cuatro años, que inició en noviembre de 2009, cuando Laboratorios Silanes entregó la primera aplicación provisional a la Oficina de Patentes y Marcas de Estados Unidos. The patent was granted after extensive analysis process four years, which began in November 2009 when Laboratorios Silanes delivered the first provisional application to the Patent and Trademark Office United States.
Un año antes, en 2008, la empresa recibió la exclusiva de explotación de la tecnología de los anticuerpos de tiburón, otorgada por el CICESE. A year earlier, in 2008, the company received exclusive exploitation of technology shark antibodies, awarded by the CICESE. En ese centro público de investigación fue desarrollada la nueva tecnología por un equipo encabezado por el doctor Alexei Licea. In that public research new technology was developed by a team led by Dr. Alexei Licea.
“La patente se otorgó a una tecnología ya una forma de explotación. "The patent was granted to a technology and a form of exploitation. En Laboratorios Silanes ya teníamos experiencia en el trabajo con anticuerpos de caballo, pero los anticuerpos de tiburón son moléculas mucho más pequeñas que se pueden reproducir mediante técnicas de Ingeniería Genética; son muy resistentes a las condiciones ambientales, mantienen su actividad a diferentes temperaturas, llegan rápidamente a su molécula blanco y desde el punto de vista de la tecnología para aplicaciones terapéuticas da muchas ventajas”, explicó Antonio L. At Laboratorios Silanes already had experience in working with horse antibodies, but antibodies of shark are much smaller molecules that can be played by genetic engineering techniques, are very resistant to environmental conditions, maintain their activity at different temperatures arrive quickly to its target molecule and from the point of view of the technology for therapeutic applications provides many advantages, "said Antonio L. Silanes, presidente de Grupo Silanes, que se alió con CICESE desde hace cinco años. Silanes Silanes Group president, that allied with CICESE five years.
CICESE es un centro de la red Conacyt con 40 años de experiencia en el ámbito científico nacional e internacional, ubicado en la costa de Ensenada, Baja California, en cercanía con el observatorio de la UNAM y frente a la Universidad Autónoma de Baja California. CICESE is a Conacyt network center with 40 years of experience in national and international scientific field, located off the coast of Ensenada, Baja California, in proximity to the UNAM observatory opposite the Autonomous University of Baja California.
La recién obtenida patente, da protección para la explotación comercial de la tecnología en Estados Unidos, país que representa el 50 por ciento del mercado de medicamentos en el mundo. The newly granted patent provides protection for the commercial exploitation of the technology in the United States, which represents 50 percent of the pharmaceutical market in the world. Otras solicitudes de patente se encuentran en trámite para su futura explotación en otras naciones. Other patent applications are pending for future exploitation in other nations.
Dos de los síntomas que atienden los nuevos biofármacos son la inflamación de las arterias y la neovascularización en las retinas. Two of the symptoms that serve the new biopharmaceutical are inflammation of the arteries and neovascularization in the retinas. Ambos se manifiestan en personas con diabetes y si se descuidan pueden provocar ceguera. Both are manifested in people with diabetes and if neglected can lead to blindness.
Fuente: Su médico Source: His medical

lunes, 7 de octubre de 2013

Prevention & Treatment of Diabetes

If you have a family history or other risk factors for diabetes or if you have been diagnosed with prediabetes, there are a number of healthy living tips you can follow to prevent or delay the onset of diabetes. If you have already been diagnosed with diabetes, these same tips can slow the progression of the disease.
Many studies show that lifestyle changes, such as losing weight, eating healthy and increasing physical activity can dramatically reduce the progression of type 2 diabetes and are important to controlling type 1 diabetes. These lifestyle changes can help minimize other risk factors as well, such as high blood pressure and blood cholesterol, which can have a tremendous impact on people with diabetes.
In many instances, lifestyle changes must be complemented by a regimen of medications to control blood glucose levels, high blood pressure and cholesterol as well as to prevent heart attack and stroke, which claim the lives of many diabetes patients.
By working with your health care team, you can set personal treatment goals, monitor your critical health numbers, and successfully manage diabetes while preventing complications from diabetes.

Diabetes and Stroke
A multi-part series on diabetes and stroke from Stroke Connection magazine:
Diabetes & Stroke
Understanding how to manage these co-occurring conditions.

The Diabetes & CVD Connection
We talked to Dr. Prakash Deedwania about the relationship between diabetes and cardiovascular disease.

Tips for Keeping on Track 
Diabetes requires constant monitoring, especially for those who use insulin. In addition to medication, lifestyle prescriptions must be adhered to. Helpful tips on how to manage medications and lifestyle prescriptions.

Treating Diabetes with Diet and Exercise
Many people with diabetes do not have to take insulin. We talked to endocrinologist Dr. Dan Mihailescu, Assistant Professor of Medicine and Director of the Diabetes Education Program at the University of Illinois at Chicago about controlling diabetes through diet and exercise.

Caregivers and Diabetes

Caregivers of survivors with diabetes often find themselves doing double duty as they face the reality of keeping diabetes under control for their loved ones. We talked with cardiologist Mikhail Khosiborod of Kansas City about the most important issues faced by caregivers in this challenging situation.

miércoles, 25 de septiembre de 2013



domingo, 22 de septiembre de 2013

Type 1 Diabetes Not Controlled in Teens

Glucose control remained inadequate in a cohort of teens with type 1 diabetes, and many of these young patients already had microvascular complications, a British observational study found.
Among a group of 96 adolescents treated at multidisciplinary young adult clinics, the mean glycosylated hemoglobin (HbA1c) level was 10%, and only 9.4% had levels below the recommended 7.5%, according to Christine Eiser, PhD, of the University of Sheffield, and colleagues.
And in a subgroup who had been diagnosed with type 1 diabetes more than 7 years earlier, 46.9% showed signs of nonproliferative retinopathy, the researchers reported online in Diabetic Medicine.
A retrospective study done a decade ago found that in a group of teens and young adults, glycemic control was suboptimal, clinic visits were sporadic, and complications were common.
The U.K.'s National Institute for Health and Care Excellence has noted that young patients with type 1 diabetes have special concerns that need to be addressed, including mental health problems.
Despite this attention, and advances in treatment, technology, and delivery systems, young patients in the U.K. appeared to be faring worse than those elsewhere in Europe.
To see if that pattern of inadequate disease control persisted, Eiser's group conducted a study between November 2010 and August 2011 that included 60% female participants whose mean age was 18 years.
Depression and anxiety were measured on the Hospital Anxiety and Depression Scale, with a cutoff point of 8 or higher suggesting a clinical diagnosis, and eating disorders were assessed on the Diabetes Eating Problem Survey, with cutoff scores of 2.5 or higher.
Most participants were white and living with their parents, and three-quarters were still in school.
They had been diagnosed an average of 8 years earlier.
A total of 76% were receiving multiple injections each day, 12.5% were on twice-daily insulin, and 11.5% were using insulin pumps.
Mean HbA1c level was higher among girls and young women, at 10.4%, than among their male counterparts, whose mean level was 9.5%.
Levels were lower for those using insulin pumps (9.2%) than for those having multiple daily injections (9.9%) or taking insulin twice daily (11.2%).
Failure to keep clinic appointments was higher, at 13.7%, in those who had been treated at the center for more than 2 years than for those treated for less than a year (10.5%).
Referrals to a clinical psychologist had been made for 21.9%, and 17.9% had kept at least one appointment.
Overall, 26.6% of patients had symptoms of anxiety and 10.9% showed symptoms of depression, while 35.1% had eating disorders.
Girls had higher scores for disordered eating than boys, with average scores of 1.4 compared with 0.6.
Those who scored above the cutoff for depression had higher HbA1c levels, at 11.7%, than those scoring lower, whose mean level was 9.8% (P=0.007).
Among those who had been diagnosed more than 7 years earlier, 94.2% had had an eye exam within the previous year, 92.3% had been screened for nephropathy, and 90.4% were evaluated for hypertension.
Those levels of screening represented an improvement over rates reported in the earlier study, the researchers noted.
A total of 14.6% had an elevated albumin-to-creatinine ratio, 4.2% had microalbuminuria, and 12.8% were hypertensive.
"We have made changes to delivery of care in our clinic to meet current recommendations for transition from pediatrics, multidisciplinary clinics, and psychological support. This has been successful to the extent that some 17.9% of young people accessed psychological support," they observed.
Nonetheless, levels of HbA1c remain too high and complications are frequent.
"Improved technologies offer the potential for better control only when the considerable burden shouldered by young people in assuming responsibility for their self-care and achieving optimal glycemic control is also addressed," they concluded

miércoles, 11 de septiembre de 2013

Ingredients to Make Any Diabetic Menu Delicious

Preparing a diabetic menu does not have to be boring! This article is the second part to 8 Easy Tips for Creating a Diabetic Menu. Ah, now where was I? I remember, flavor. No, not just flavor, spark and decadence!

Mayonnaise and Sour Cream Sauces

Just the way tartar sauce adds a lot of flavor and balance to a boring fish dish, mayonnaise and sour cream sauces add that extra bit of zip to almost any dish. Or it can be as simple as adding horseradish to sour cream for steak and fish, or adding chopped capers and shallot to create a Royal Caper sauce, using a remoulade sauce (see recipe) on anything and everything from a cheese sandwich to that turkey loaf I mentioned. Too bland?  Want something hotter? Add curry or chopped hot peppers to either mayonnaise or sour cream for spicy taste. Only your imagination and creativity is the limit.

Mustard

diabetic menuI can’t talk about adding flavor to a recipe without mentioning mustards. A small amount of mustard adds spark to chicken and to pork and to beef. It gives it another layer on the palate. Please don’t limit yourself to yellow mustard. Don’t get me wrong, I like old fashioned yellow mustard on a ham sandwich, but there are too many varieties available in the market to limit yourself to just one variety. Try a whole grain mustard. It has a very different taste and texture.

Vinegars

There are no two ways about it. If you are diabetic, salad is a big part of your diet. There are a few commercial dressings on the market that are low in carbohydrates. Ken’s Steakhouse is one I use a lot. But nothing could be easier than making your own vinaigrette dressing.
I am sure you have done this with red wine vinegar, maybe with white wine vinegar, or apple cider vinegar. I suggest that you look in the same aisle for Champagne vinegar, tarragon vinegar, raspberry vinegar (great for a salad that contains berries) and balsamic vinegar. Vinegars vary in cost.
I suggest that you buy the best one you can afford. You will use less of it and it will give you the most distinctive flavor. One of my personal favorites is ARISTON Balsamic vinegar. It comes from Greece and is thick and slightly sweet. I also use it in marinades like the pork roast I shared with you last week.

Herbs

The debate rages on about dry versus fresh. Just how many years were those dry herbs in the jar on the shelf of the “stupidmarket”? If you are concerned about the age (staleness?), go to a store that sells bulk herbs. Chances are that they are fresher there than ones the shelf. I can’t swear that it is true, but it’s a good guess. I grow a few herbs in the garden. I use them fresh all summer.
But who is kidding who, I live in Maine. Summer is very short. I will cut the herbs down at the end of the season and hang them to dry in my cellar. With tarragon, I get such a good yield that what I can’t give away fresh, I dry. Even then I might not get to it. I have had some dry for over a year.
Let me tell you that the flavor is still great. Dry is softer than fresh. The same is true for oregano and thyme. Parsley, basil and dill are available fresh all year. Use them! They store pretty well in a glass of water in the refrigerator. Used at the last minute add a real freshness to you dish. And the green color ain’t bad to look at either. The thing is to use them. I grew up in a household that used salt (far too much), pepper, garlic and onion. That was all! I never knew better. I never starved.

Versatility

It is so easy to eat a varied and fun diet even though I am type 2 diabetic. By using, citrus, compound butters, soup cubes, mayonnaises, mustards, vinegars, and herbs, I dine very well indeed. No, scratch that. I dine DECADENTLY!